Vitamin D supplementation: Pearls for practicing clinicians
CLEVELAND CLINIC JOURNAL OF MEDICINE VOLUME 89 • NUMBER 3 MARCH 2022
DOI: 10.3949/ccjm.89a.21021
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Why D3 is preferred over D2
Vitamin D3 seems more appropriate than D2 to sustain adequate levels of 25OHD: a pharmacokinetic approach
B Oliveri, S R Mastaglia, G M Brito, M Seijo, G A Keller, J Somoza, R A Diez, G Di Girolamo, Eur J Clin Nutr. 2015 Jun;69(6):697-702. doi: 10.1038/ejcn.2015.16. Epub 2015 Mar 18.
Effects of vitamin D2-fortified bread v. supplementation with vitamin D2 or D3 on serum 25-hydroxyvitamin D metabolites: an 8-week randomised-controlled trial in young adult Finnish women
Suvi T Itkonen, Essi Skaffari, Pilvi Saaristo, Elisa M Saarnio, Maijaliisa Erkkola, Jette Jakobsen, Kevin D Cashman, Christel Lamberg-Allardt, Br J Nutr. 2016 Apr 14;115(7):1232-9. doi: 10.1017/S0007114516000192. Epub 2016 Feb 11.
Effects of High-Dose Vitamin D2 Versus D3 on Total and Free 25-Hydroxyvitamin D and Markers of Calcium Balance
Albert Shieh,corresponding author Rene F. Chun, Christina Ma, Sten Witzel, Briana Meyer, Brandon Rafison, Leon Swinkels, Tonnie Huijs, Sam Pepkowitz, Brett Holmquist, Martin Hewison, and John S. Adams, J Clin Endocrinol Metab. 2016 Aug; 101(8): 3070–3078. Published online 2016 May 18. doi: 10.1210/jc.2016-1871
Vitamin D2 Is Much Less Effective than Vitamin D3 in Humans
LAURA A. G. ARMAS, BRUCE W. HOLLIS, AND ROBERT P. HEANEY, The Journal of Clinical Endocrinology & Metabolism, Volume 89, Issue 11, 1 November 2004, Pages 5387–5391
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The case against ergocalciferol (vitamin D2) as a vitamin supplement
Lisa A Houghton and Reinhold Vieth, Am J Clin Nutr 2006;84:694 –7
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Vitamin D: A Rapid Review
Mark A. Moyad, MD, MPH, Dermatology Nursing. 2009;21(1)
Vitamin D: A Rapid Review Read More »
Vitamin D3 Is More Potent Than Vitamin D2 in Humans
Robert P. Heaney, Robert R. Recker, James
Grote, Ronald L. Horst, and Laura A. G. Armas, J Clin Endocrinol Metab, March 2011, 96(3):E447–E452
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Long-term vitamin D3 supplementation is more effective than vitamin D2 in maintaining serum 25- hydroxyvitamin D status over the winter months
Victoria F. Logan, Andrew R. Gray, Meredith C.
Peddie, Michelle J. Harper, and Lisa A. Houghton, British Journal of Nutrition (2013), 109, 1082–1088
Bioavailability of Vitamin D2 and D3 in Healthy Volunteers, a Randomized Placebo-Controlled Trial,
Ulrike Lehmann, Frank Hirche, Gabriele I. Stangl, Katja Hinz, Sabine Westphal,and Jutta Dierkes, J Clin
Endocrinol Metab, November 2013, 98(11):4339 – 4345